Desi expert traces ‘great grandpa of SARS CoV 2 India News
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The effort to hint the origins of SARSCoV-2, which causes Covid-19, wouldn’t have been as exacting had ‘patient zero’ been discovered by now. In January, the WHO mentioned we’d “never find who patient zero was”. But there was a technique to establish the ancestor of the virus, a molecular epidemiologist from India discovered by “predicting” historical past with knowledge. The ancestor, or progenitor genome, it turned out, had been round since no less than October 2019 and survived until March 2020.
The progenitor is the genome of the coronavirus present in that one one who unfold it to others, after which everybody else acquired descendants of that coronavirus. “Everyone was inquisitive about new strains after December 24, 2019 (when the primary case was reported). We needed to know which pressure got here first, the progenitor,” Dr Sudhir Kumar, director of the Institute for Genomics and Evolutionary Medicine, Temple University, instructed TOI. “We can tell you the time of the ancestor’s origin was around or before October 2019.” Two months earlier than the primary case, predating by a large margin the reference genome sequence that’s getting used now.
But the progenitor didn’t die. “We found it was still going around after the offspring started spreading. It was present in China in January 2020 and US in March 2020,” mentioned Kumar, who’s initially from Delhi. So, the ancestor virus didn’t want a mutation to unfold. “It was ready to go on its own. SARSCoV-2 is its great-grandkid, three mutations away.”
To arrive at this, Kumar and his staff tailored a course of referred to as mutation order evaluation, typically used to review mutations in tumours. The findings have been printed within the Oxford Academic journal ‘Molecular Biology and Evolution.

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